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연구/발표논문

유영춘 교수 (Yoo, Yung Choon)

연구분야

  • 면역조절제의 개발과 면역학적 기전 해석에 관한 연구
  • 면역 adjuvant를 탐색하여 vaccine개발과 종양의 면역학적 치료 및 예방에 응용하고자 하는 연구
  • 종양세포 apoptosis유도 물질을 탐색하고, 그 작용기전을 해석하는 연구
  • 질병의 예방,치료 및 진단에 응용가능한 단일클론 항체의 생산과 그 항체를 이용한 kit개발에 관한 연구
  • 천연물로부터 신종 생리활성물질의 탐색과 개발에 관한 연구

최근 대표논문

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미생물학교실 유영춘 교수 최근 대표논문 : 미생물학교실 유영춘 교수 최근 대표논문에 대한 내용입니다.
대표논문
1. The immunomodulatory activity of the water-extract of Korean mistletoe fruit to activate murine peritoneal macrophages. 생약학회지, 41(2):122-129 (2010)
2. Improved isolation methods for mucosal leukocytes from small and large intestines in rats. Biosci. Biotechnol. Biochem., 73(8):1732-1740 (2009)
3. Adjuvant activity of Cudrania tricuspidata water extracts to enhance antigen specific humoral and cellular immune responses. J. Kor. Soc. Appl. Biol. Chem., 52(3):234-240 (2009)
4. Immune-enhancing activities of low molecular weight b-glucan depolymerized by gamma irradiation. Radiation Physics and Chemistry, 78:433-436 (2009)
5. Gamma irradiation reduces the immunological toxicity of doxorubicin, anticancer drug. Radiation Physics and Chemistrey, 78:425-428 (2009)
6. Effect of Korean mistletoe (Viscum album coloratum) extract (KME) on the extension of life span in silkworm moth, Bombyx mori. Kor. J. Pharmacogn., 39(4):310-315 (2008)
7. Effect of gamma irradiation on sleen cell function and cytotoxicity of doxorubicin. Chemo-Biological Interactions, 173:205-214 (2008)
8. Korean mistletoe lectin (KML-IIU) and its subchains induce nitric oxide (NO) production in murine macrophage cells. Journal of Biomedical Science, 15:197-204 (2008)
9. Immunomodulating activity of a fucoidan isolated from Korean Undaria pinnatifida Sporophyll. ALGAE, 22(4):333-338 (2007)
10. Isolation and characterization of two Korean kistletoe lectins. Journal of Biochemistry and Molecular Biology, 40(6):959-965 (2007)
11. The IL-6/sIL-6R treatment of a malignant melanoma cell line enhances susceptability to TNF-a-induced apoptosis. Biochem. Biophy. Res. Commun., 354, 985-991 (2007)
12. Ovalbumin modified by gamma irradiation alters its immunological functions and allergic responses. Int. Immunopharmacol., 7, 464-472 (2007)
13. Isolation of fatty asids with anticancer activity from Protaetia brevitarsis larva. Arch. Pharm. Res., 30, 361-365 (2007)
14. Determination of minimal sequence of bovine lactoferricin responsible for apoptosis induction in THP-1 cells. Lab. Anim. Res., 22(2), 181-185 (2006)
15. Purification of native Ag85 complex, 38-kDa and MTB12 protein antigens from the culture filtrate of Mycobacterium tuberculosis. J. Bacteriol. Virol., 36(4), 211-220 (2006)
16. Immunomodulating and antitumor activities of the protein fraction of Korean mistletoe in mice. Lab. Anim. Res., 22(4), 383-387 (2006)
17. Transcriptional regulation of the mouse interleukin-2 receptor beta chain gene by Ets and Egr-1. Biochem. Biophys. Res. Commun., 329, 1094-1101 (2005)
18. Induction of TNF-a, IL-12, IL-10, MCP-1 and IL-8 in human peripheral blood monocytes in response to the cell wall-associated Triton X-100 soluble protein (TSP) antigens of Mycobacterium tuberculosis. J. Bacteriol. Virol., 35(3), 227-237 (2005)
19. Establishment of a strategy for the promotion of an active participation in the IAEA programs in the field of human health. 핵의학기술, 10(1), 117-121 (2005)
20. Antitumor activity of the Korean mistletoe extracts fermented with Lactobacillus acidophilus in mice. Lab. Anim. Res., 21(4), 391-396 (2005)
21. Suppression of iNOS expression by Phlorotannins in chronic exposure of skin to UVB radiation. Lab. Anim. Res., 21(4), 385-389 (2005)

이정림 교수 (Lee, Jung lim)

연구분야

  • 이식면역관용 기전에 관한 연구
  • 면역관용에서 조절 T 림프구의 역할에 대한 연구
  • 수지상세포의 면역 조절 기능에 대한 연구
  • 생체 기능성 물질의 면역활성에 대한 연구

최근 대표논문

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미생물학교실 이정림 교수 최근 대표논문 : 미생물학교실 이정림 교수 최근 대표논문에 대한 내용입니다.
대표논문
1. 한국산 겨우살이 열매추출물의 마우스 복강 대식세포 면역활성화 효과. 생약학회지, 41:122-129, 2010
2. Analysis of indirect pathway CD4+ T cells in a patient with metastable tolerance to a kidney allograft. Transplant Immunology, 20:203-208, 2009
3. Adjuvant Activity of cudrania tricuspidata Water Extracts to Enhance Antigen Specific Humoral and Cellular Immune Responses. J. Korean Soc. Appl. Biol. Chem., 52(3):234-240, 2009
4. The Modulation of Cell Wall-Associated Triton X-100 Soluble Protein (TSP) Antigens of Mycobacterium tuberculosis on Murine Dendritic Cells. Laboratory Animal Research, 24(4):659-667, 2008
5. 결핵균 단백항원 자극에 의한 대식세포의 TNF-a 및 IL-6 생성과 ERK 활성화. Immune Network, 7(1):26-30, 2007
6. Human CD4+CD25 low Adaptive T regulatory Cells Suppress Delayed-type Hypersensitivity during Transplant Tolerance. J. Immunol., 178: 3983-3995, 2007
7. Isolation of fatty asids with anticancer activity from Protaetia brevitarsis larva. Arch. Pharm. Res., 30: 361-365, 2007
8. Purification of native Ag85 complex, 38-kDa and MTB12 protein antigens from the culture filtrate of Mycobacterium tuberculosis. J. Bacteriol. Virol., 36(4): 211-220, 2006
9. Immunomodulating and antitumor activities of the protein fraction of Korean mistletoe in mice. Lab. Anim. Res., 22(4): 383-387, 2006
10. Determination of the Minimal Sequence of Bovine Lactoferricin Responsible for Apoptosis Induction in THP-1 Cells. Lab. Anim. Res., 22 (2):181-185, 2006
11. Induction of TNF-a, IL-12, IL-10, MCP-1 and IL-8 in human peripheral blood monocytes in response to the cell wall-associated Triton X-100 soluble protein (TSP) antigens of Mycobacterium tuberculosis. J. Bacteriol. Virol., 35(3): 227-237, 2005

박석래 교수 (Park, Seok-Rae)

연구분야

  • B 세포의 면역글로블린 중쇄동형전환 (Ig heavy chain isotype switching) 기작에 대한 연구
  • AID 및 HoxC4 발현에 관여하는 자극물질, 신호전달인자 및 전사인자의 발굴 및 분석
  • PAMP:PRR (TLR 및 NLR) 체계의 활성이 B 세포 분화 및 항체동형전환에 미치는 영향을 조사/분석
  • 비타민 A (retinoic acid) 및 락토페린이 IgA 항체전환에 미치는 영향을 조사/분석

최근 대표논문

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미생물학교실 박석래 교수 최근 대표논문 : 미생물학교실 박석래 교수 최근 대표논문에 대한 내용입니다.
대표논문
1. TGF-beta1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions. Eun-Hee Nam*, Seok-Rae Park*, and Pyeung-Hyeun Kim. Experimental & Molecular Medicine, 42(9):606-613,September, 2010. (*These authors contributed equally to this work)
2. 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination. Zhenming Xu, Zsolt Fulop, Guikai Wu, Egest J. Pone, Jinsong Zhang, Thach Mai, Lisa M. Thomas, Ahmed Al-Qahtani, Clayton A. White, Seok-Rae Park, Petra Steinacker, Zenggang Li, John Yates, III, Bruce Herron, Markus Otto, Hong Zan, Haian Fu, and Paolo Casali. Nature Structural & Molecular Biology, 17(9):1124-1135, September, 2010.
3. The HAT domain of p300 is critical for the basal Ig germ-line alpha promoter activity while Stat-1 and E1A act as strong repressors. Seok-Rae Park, Mee-Hyeun Jung, and Pyeung-Hyeun Kim. Genes & Genomics, 32(4):369-374, August, 2010.
4. IFN-gamma down-regulates TGF-beta1-induced IgA expression through Stat1 and p300 signaling. Seok-Rae Park, Mee-Hyeun Jung, Seong-Hyun Jeon, Mi-Hee Park, Kyoung-Hoon Park, Mi-Ra Lee, and Pyeung-Hyeun Kim. Molecules and Cells, 29(1):57-62, January 2010.
5. IL-4 stimulates mouse macrophages to express APRIL through p38MAPK and two different downstream molecules, CREB and Stat6. Young-Saeng Jang, Hyun-A Kim, Seok-Rae Park, Mi-Ra Lee, Jae-Bong Park, and Pyeung-Hyeun Kim. Cytokine, 47(1):43-47, July 2009.
6. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Seok-Rae Park, Hong Zan, Zsuzsanna Pal, Jinsong Zhang, Ahmed Al-Qahtani, Egast J. Pone, Zhenming Xu, Thach Mai, and Paolo Casali. Nature Immunology, 10(5):540-550, May 2009.
7. Analyses of TGF-beta1-inducible Ig germ-line gamma2b promoter activity: involvement of Smads and NF-kappaB. Goo-Young Seo, Seok-Rae Park, and Pyeung-Hyeun Kim. European Journal of Immunology, 39(4):1157-1166, April 2009.
8. Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination. Hong Zan, Jinsong Zhang, Sona Ardeshna, Zhenming Xu, Seok-Rae Park, and Paolo Casali. Autoimmunity, 42(2):89-103, February 2009.
9. Regulation of aicda Expression and AID Activity: Relevance to Somatic Hypermutation and Class Switch DNA Recombination. Zhenming Xu, Egest J. Pone, Ahmed Al-Qahtani, Seok-Rae Park, Hong Zan, and Paolo Casali. Critical Reviews in Immunology, 27(4):367-397, October 2007.
10. IL-4-induced AID expression and its relevance to IgA class switch recombination. Ran Ju Kim, Hyun-A Kim, Jae-Bong Park, Seok-Rae Park, Seong-Hyun Jeon, Goo-Young Seo, Dong-Wan Seo, Su Ryeon Seo, Gie-Taek Chun, Nam-Soo Kim, Se-Won Yie, Woo-Hyeon Byeon, and Pyeung-Hyeun Kim. Biochemical and Biophysical Research Communications, 361(2):398-403, September 2007.
11. Mechanisms Underlying the Effects of LPS and Activation-induced Cytidine Deaminase on IgA Isotype Expression. Seok-Rae Park, Hyun-A Kim, Sung-Ki Chun, Jae-Bong Park, and Pyeung-Hyeun Kim. Molecules and cells, 19(3):445-451, June 2005.
12. Analysis of transforming growth factor- 1-induced Ig germ-line 2b transcription and its implication for IgA isotype switching. Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, Janet Stavnezer, and Pyeung-Hyeun Kim. European Journal of Immunology, 35(3):946-956, March 2005.