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연구/발표논문

연구분야

이경복교수

당질생화학

  • Glycoprotein의 분리 및 당구조에 관한 연구
  • Proteoglycans의 생리활성에 관한 연구
  • 항혈액응고작용에 관한연구

천연물화학

  • 천연물의 생리활성에 관한 연구
  • 항당뇨, 항산화, 항고혈압, 면역조절 활성에 관한 연구

오상묵 교수

단백질 생화학

  • 암 성장, 전이 및 사멸 또는 특이 염증 반응에 있어서 인산화효소 TOPK의 역할 탐구
  • DNA repair, 전사, 유전자 발현, 암 억제/촉진 등에 관련되어 있는 여러 인자들의 수모화 (sumoylation)를 조사하고 특이 신호 전달반응 (DNA damage agents, inflammatory stimuli등)에 있어서, 그 수모화의 역할 탐구

문민호 교수

알츠하이머병

  • 가 축적되는 세포에 특이적으로 발현되는 핵수용체 Nurr1의 역할 연구
  • 내분비 호르몬인 그렐린의 알츠하이머병 치료제로써의 가능성 연구
  • 알츠하이머병에서 손상 된 뇌를 내인성 줄기세포의 활성화 및 줄기세포 이식으로 재생 연구
  • 천연물 중 알츠하이머병의 치료후보 물질 탐색 연구

대표논문

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생화학교실 대표논문 : 생화학교실 대표논문에 대한 내용입니다.
대표논문
Blood-brain barrier-permeable fluorone-labeled dieckolsacting as neuronal ER stress signaling inhibitors Jong Hwan Kwak, Zhigang Yang, Byungkwon Yoon, Yanxia He b, Soojin Uhm b,Hyeon-Cheol Shin, Bong Ho Lee, Yung Choon Yoo, Kyung Bok Lee*,Seung-Yun Han,* Jong Seung Kim(2015) Biomaterials 61, 52-60
Synthesis of rhodamine-labelled dieckol: itsuniqueintracellular localization and potentanti-inflammatory activityS, Yang Z, Kang EJ, Lee BH, Han SY, Yoo YC, Lee KB*, Kim JS*. (2014) CHEMICAL COMMUNICATIONS 50, 13045-13048
Suppression of NF-kappa B by Dieckol Extracted fromEcklonia cava Negatively Regulates LPS Induction ofInducible Nitric Oxide Synthase GeneHye-Jin Choi, Jung-Hwan Park, Bong Ho Lee, Hee Youn Chee, Kyung Bok Lee, Sang-Muk Oh(2014) APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173, 4, 957-967
Carbohydrate-Containing Moleculesas Potential Biomarkers inColon CancerJoo EJ, Weyers A, Li G, Gasimli L, Li L, Choi WJ, Lee KB*, Linhardt RJ*.(2014) OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY 18.4
High Sensitivity Detection of Active Botulinum Neurotoxin by Glyco-Quantitative Polymerase Chain-ReactionKwon SJ, Jeong EJ, Yoo YC, Cai C, Yang GH, Lee JC, Dordick JS, Linhardt RJ, Lee KB*.(2013) ANALYTICAL CHEMISTRY 86 (5),2279?2284
RIP2/RICK-Dependent Cytokine Production Upon Yersiniaenterocolitica Infection in Macrophages with TLR4 DeficiencyY.-J. Jeong1, C.-H. Kim, .C. Kim, S.-M. Oh, K.-B. Lee, J.-H. Park1,* and D.-J. Kim1,*(2013) SCANDINAVIAN JOURNAL OF IMMUNOLOGY 78(5) 401-407
Microanalysis of stomach cancer glycosaminoglycans Weyers A, Yang B, Park JH, Kim YS, Kim SM, Lee SE, Zhang F, Lee KB*, Linhardt RJ*.(2013) GLYCOCONJUGATE JOURNAL 30, 701-707
The role of nucleotide-binding oligomerization domain 1during cytokine production by macrophages in response toMycobacterium tuberculosis infection. Lee JY, Hwang EH, Kim DJ, Oh SM, Lee KB, Shin SJ, Park JH. Immunobiology. 2015 Jul 26. pii: S0171-2985(15)30039-5.
SUMO Proteins are not Involved in TGF-β1-induced, Smad3/4-mediated Germline α Transcription, but PIASy Suppresses it in CH12F3-2A B Cells. Lee SH, Kim PH, Oh SM, Park JH, Yoo YC, Lee J, Park SR. Immune Netw. 2014 Dec;14(6):321-7.
Suppression of NF-κB by dieckol extracted from Ecklonia cava negatively regulates LPS induction of inducible nitric oxide synthase gene. Choi HJ, Park JH, Lee BH, Chee HY, Lee KB, Oh SM. Appl Biochem Biotechnol. 2014 Jun;173(4):957-67.
Activation of TOPK by lipopolysaccharide promotes induction of inducible nitric oxide synthase through NF-κB activity in leukemia cells. Park JH, Jeong YJ, Won HK, Choi SY, Park JH, Oh SM. Cell Signal. 2014 May;26(5):849-56.
RIP2/RICK-dependent cytokine production upon Yersinia enterocolitica infection in macrophages with TLR4 deficiency. Jeong YJ, Kim CH, Kim JC, Oh SM, Lee KB, Park JH, Kim DJ. Scand J Immunol. 2013 Nov;78(5):401-7.
Phosphorylation of IκBα at serine 32 byT-lymphokine-activated killer cell-originated protein kinase isessential for chemoresistance against doxorubicin in cervical cancer cells. Park JH, Yoon DS, Choi HJ, Hahm DH, Oh SM. J Biol Chem. 2013 Feb 1;288(5):3585-93.
Minho Moon, Hyo Geun Kim, Lakkyong Hwang, Ji-Hyung Seo, Sehee Kim, Sunyoung Hwang, Soonyong Kim, Dahm Lee, Hyunju Chung, Myung Sook Oh, Kyung-Tae Lee, and Seungjoon ParkNeuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse modelof Parkinson’s disease by blocking microglial activation,Neurotoxicity Research 15:332?347 (2009)
Minho Moon, Sehee Kim, Lakkyong Hwang, Seungjoon Park, Ghrelin regulates hippocampal neurogenesis in adult mice.Endocrine Journal, 56(3):525-531 (2009)
Minho Moon, Jin Gyu Choi, Dong Woo Nam, Hyun-Seok Hong, Young-Ju Choi, Myung Sook Oh and Inhee Mook-JungGhrelin ameliorates cognitive dysfunction andneurodegeneration in intrahippocampal Aβ (1-42)oligomer-injected mice.Journal of Alzheimer’s Disease, 1;23(1):147-59 (2010)
Minho Moon, Hyun-Seok Hong, Dong Woo Nam, Sung Hoon Baik, Hyundong Song, Sun-Young Kook, Yong soo Kim, Jeewoo Lee and Inhee Mook-Jung, Intracellular Aβ accumulation in calcium-bindingprotein-deficient neurons leads to Aβ plaque formation inanimal models of Alzheimer’s disease.Journal of Alzheimer’s Disease, 29(3): 615-628 (2012)
M Moon, H Song, HJ Hong, DW Nam, MY Cha, MS Oh, J Yu, H Ryu, I Mook-Jung. Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology, Cell death and differentiation, 20(4):630-8 (2013)
Minho Moon, Moon-Yong Cha, and Inhee Mook-JungImpaired Hippocampal Neurogenesis and its Enhancement with Ghrelin in 5XFAD Mice.Journal of Alzheimer’s Disease, 41(1):233-41 (2014)
Minho Moon, Jin Gyu Choi, Sun Yeou Kim, Myung Sook Oh.Bombycis excrementum reduces amyloid betaoligomer-induced memory impairments, neurodegeneration,and neuroinflammation in mice.Journal of Alzheimer’s Disease, 41(2):599-613 (2014)
Soon Min Lim, Minho Moon*, Hyein Oh, Hyo Geun Kim, Sun Yeou Kim, Myung Sook Oh. (*Co-first author),Ginger improves cognitive function via NGF-inducedERK/CREB activation in the hippocampus of the mouse. The Journal of Nutritional Biochemistry, 25(10):1058-65 (2014)